Deciphering Fact from Frenzy
Prolonged water-only fasting was recently cast in a negative light after a paper in Molecular Metabolism (Commissati, et al., 2025)1 reported that the therapy increases inflammation and may be harmful. Press quotes from senior author Luigi Fontana, MD, emphasized that the result ran counter to the study’s hypothesis that fasting would be anti-inflammatory and instead indicated the intervention might raise cardiovascular risk in some people.2 The coverage left many questioning how a longstanding, medically supervised treatment with documented benefits and a strong safety record could suddenly be portrayed as harmful.
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